As a new type of tobacco product, vape has entered the field of vision of the majority of cigarette consumers. The aroma components required in e-liquid are relatively new to the flavor and fragrance industry. China's e-liquid is sold globally. This article is mainly based on domestic vape Research progress in the field of flavors, summarizing the current problems of flavored vape products and looking forward to the future development of e-liquid, providing new ideas.
Cigarette burning and cracking will produce thousands of compounds, most of which are harmful to human body, especially tar is a carcinogen, which will seriously damage the health of smokers and passive smokers. Because nicotine in tobacco is highly addictive, it is not easy for smokers to quit it. As a result, many cigarette substitutes have appeared on the market, among which vape is the most common.
Steam-type vape uses the atomizer based on the principle of resistance wire heating to atomize the e-liquid containing nicotine, nicotine salt and flavors and fragrances into particles, thereby simulating the taste and nicotine satisfaction of traditional cigarettes, and does not produce the release of traditional cigarettes when they burn Harmful substances such as tar provide a new way of smoking for smokers, and can effectively satisfy nicotine dependence. However, the e-liquid with multiple flavors including the original flavor of tobacco is inseparable from the flavor components and aroma components added therein.
It is particularly meaningful for e-liquid manufacturers to develop and apply e-liquid that can provide consumers with a variety of flavors and is very safe. This article will analyze the current research on aroma substances in e-liquid and explore their development from the perspective of safety and stability of aroma substances.
Most e-liquids contain aroma chemicals. This is also the reason why it can be quickly accepted by smokers. These aroma substances are recognized as safe in various food fragrance regulations. But in vape, because of its heating in the atomizer and following the smoke particles into the lungs, its safety needs to be discussed further.
For the regular e-liquid products of e-liquid manufacturers, the data may be obtained through testing experiments, and the data will finally be obtained through the testing agency to obtain safety data. But it is different for OEM e-liquid products, they may configure the appropriate flavor according to the customer's requirements, and they will not care about the detection of e-liquid.
Tierney et al. identified and measured 30 aroma chemicals in e-liquids, with flavor chemicals in the range of approximately 1-4% (10-40 mg/mL) in many e-liquids after GC/MS analysis ; Nicotine in the range of 0.6-2.4% (6-24mg/mL). A large number of flavoring substances are aldehyde compounds, which can irritate the mucosal tissue of the upper respiratory tract, but compared with the rushing feeling of traditional cigarettes, such slight stinging pain will be ignored by people. But it does create toxicological concerns.
And research by Kosmider's group shows that although many of the flavorings used in vape are generally considered safe for use in food, concerns have been raised about the inhalation toxicity of these chemicals. Benzaldehyde, a key ingredient in natural fruit flavors, has been shown to irritate the respiratory tract in animal and occupational exposure studies.
Considering the compound's potential inhalation toxicity Although vape appears to be a novel smoking modality that reduces harm for smokers, the findings suggest that use of these products may lead to repeated inhalation of benzaldehyde, given the health risks associated with long-term inhalation of flavoring ingredients such as benzaldehyde Uncertainty, clinicians need to be aware of this emerging risk and ask patients about the use of flavored vapes.
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